Non-invasive, active patch technology for enhanced delivery of topical formulations
Power Paper’s delivery platform combines drug delivery and electrically promoted delivery mechanisms such as iontophoresis - a well-known medical process in which ionized substances penetrate the skin via an appropriate electrical current - and electro-osmosis, a typical accompaniment to iontophoresis.
Positioned to become the topical delivery device of choice in the 21st century, the company's ground-breaking Power Patch™ uses electrical energy to enhance the delivery of drugs through biological membranes such as the skin or the nail. Completely self-contained, the disposable, thin and flexible patch is comprised of printed electrodes, batteries, and an electronic control unit. The drug formulation is applied under the active electrode.
The delivery depth of the Power Patch ™ can be configured according to the end application. For example, using preset control mechanisms, it is possible to target delivery to layers of the skin or the nail or for systemic delivery. In addition to providing a vastly improved delivery mechanism for therapeutic formulations, Power Paper's patches have a number of differentiating features:
- Highly elastic and flexible
- Safe: contains no toxic chemicals and cannot overheat, explode, or cause burns or electrical shock
- Environmentally friendly: contains no hazardous materials and can be freely stored and disposed
- Competitive pricing: Suitable for mass-production at low cost; option available to manufacture fully-integrated, printable patches
- Strong IP protection: More than 50 issued patents worldwide
Power Paper has developed a “Fast Screening System”, which utilizes an in-vitro modified Franz Cell System, equipped with the necessary components to exert a micro-powered electronic current, simulating the expected effect of the patch. This system is employed to rapidly screen and select the candidate active molecules and to optimize their therapeutic formulations. Power Paper’s “Fast Screening” system serves to efficiently and rapidly screen candidate molecules and their formulations in an in vitro manner, while at the same time determining the time and current necessary to deliver them into the skin.